Identification of Unique miRNA Biomarkers in Colorectal Adenoma and Carcinoma Using Microarray: Evaluation of Their Putative Role in Disease Progression
Table 3
Differential expression of key miRNAs and their specific gene targets in colon carcinoma.
miRNAs
miRNA expression
miRNA regulated genes
Gene expression
hsa-let-7i*Ω
Up
AKAP5, EPHA4, KLF9, and PPP1R12B
Down
hsa-miR-107 †
Up
Down
hsa-miR-133b
Up
Down
hsa-miR-135b
Up
Down
hsa-miR-141*Ω
Up
FOXA1, NR3C1, and PRKACB
Down
hsa-miR-152
Up
Down
hsa-miR-181a*Ω
Up
AKAP5, KITLG, MARCKS, NR3C1, PLCL2, and PPP1R12B
Down
hsa-miR-29a *Ω
Up
AKAP5,
Down
hsa-miR-346
Up
Down
hsa-miR-200c *Ω
Up
, KLF9, LPAR1, MARCKS, NR3C1, PPP1R12B, and PRKACB