International Scholarly Research Notices

Research Article

Identification of Unique miRNA Biomarkers in Colorectal Adenoma and Carcinoma Using Microarray: Evaluation of Their Putative Role in Disease Progression

Differential expression of key miRNAs and their specific gene targets in colon carcinoma.


miRNAs	miRNA expression	miRNA regulated genes	Gene expression

hsa-let-7i^*Ω	Up	AKAP5, EPHA4, KLF9, and PPP1R12B	Down
hsa-miR-107 ^†	Up		Down
hsa-miR-133b	Up		Down
hsa-miR-135b	Up		Down
hsa-miR-141^*Ω	Up	FOXA1, NR3C1, and PRKACB	Down
hsa-miR-152	Up		Down
hsa-miR-181a^*Ω	Up	AKAP5, KITLG, MARCKS, NR3C1, PLCL2, and PPP1R12B	Down
hsa-miR-29a ^*Ω	Up	AKAP5,	Down
hsa-miR-346	Up		Down
hsa-miR-200c ^*Ω	Up	, KLF9, LPAR1, MARCKS, NR3C1, PPP1R12B, and PRKACB	Down
hsa-miR-34a^*Ω	Up	IL6R, KITLG	Down
hsa-miR-7	Up		Down
hsa-miR-25	Up		Down
hsa-miR-125a^*Ω	Down	TNFAIP3^Ω	Up
hsa-miR-137	Down	ZAK^Ω	Up
hsa-miR-143^*Ω	Down	ITGA6	Up
hsa-miR-145^*Ω	Down	ABCC1, ATRX, ETS2, INHBB, MYC^#, and SCARB1	Up
hsa-miR-195^*Ω	Down	AXIN2, CXCL10, GABRE, IRAK2, KSR1, PSME3, SERPINE2, TGFBR3, UBE2S, VEGFA, ZAK^Ω, and ZYX	Up
hsa-miR-26a^*Ω	Down	CDK8, COL1A2, INHBB, PMAIP1, PPP1R3D, and STK4	Up
hsa-miR-34b^*Ω	Down	ZAK^Ω	Up
hsa-miR-9^Ω	Down	DNAJB1, FOXO3^#, INHBB, ITGA6, KSR1, NCOA3, NEDD4, and PPAT	Up

Tumour suppressor, ^#oncogene, ^†oncomirs, and *mature miRNA sequence from the opposite arm of the precursor.