Oxidative Stress and Proteostasis Network: Culprit and Casualty of Alzheimer’s-Like Neurodegeneration
Figure 1
Interplay between oxidative stress and proteostasis network. Low amount of ROS induces the adaptive cellular apparatus such as the heat shock responses, UPR, and autophagy (green arrows). A chronic exposure to ROS leads to accumulation of oxidized proteins as well as damaging (red inhibition arrows) specific component of PQC, thus exacerbating the accumulation of unfolded/misfolded proteins.