Review Article
Oxidative Stress and Proteostasis Network: Culprit and Casualty of Alzheimer’s-Like Neurodegeneration
Table 1
List of the proteins members of the proteostasis networks identified oxidatively modified in Alzheimer's-like diseases.
| Proteostasis system | Oxidized proteins | Disease |
| Molecular chaperones | HSP90 | AD [5] | HSP60 | AD [5] | HSP32 | AD [87] | Haptoglobin | AD [94] | Alpha 2 macroglobulin | AD [94] | Serum amyloid P | AD [94] | Clusterin | AD [94] | HSC71 | DS/AD [80] |
| ER proteins | EF-Tu | AD [101] | eIF-a | AD [101] | Pin1 | AD [106] | GRP78 | DS, DS/AD [80, 81] |
| Ubiquitin-proteasome system | UCH-L1 | AD [97], DS/AD, and DS [80, 81] |
| Autophagy-lysosome system | Cathepsin D | DS [81] |
V0-ATPase | DS [81] | GFAP | DS, DS/AD [80, 81] |
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