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| Study authors | Study population | Study design | Drug used | Outcome measure | Result |
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(1) Sharp et al., 2010 [25]
| Children with severe burns, | Chart review | Propranolol | Diagnosis of ASD | No effect of propranolol in preventing ASD after 1 month |
|
| (2) Schelling et al., 1999 [24] | Adults surviving septic shock, (27 receiving the drug, 27 controls) | Retrospective case-control | Hydrocortisone 100 mg, followed by 0.18 mg/kg/hr | Diagnosis of PTSD as per Posttraumatic Stress Syndrome-10 Inventory | Significantly lower rates of PTSD in patients receiving hydrocortisone (5/27 versus 16/27 controls, ) |
|
| (3) Kobayashi et al., 2011 [26] | Adult victims of traffic accidents (; 23 receiving the drug, 232 controls) | Retrospective case-control | Salbutamol | PTSD symptoms as per CAPS | Lower CAPS scores in the salbutamol group at 6 weeks; only the re-experiencing sub-score was lower in this group after 1 year |
|
| (4) Saxe et al., 2001 [27] | Hospitalized children with burns, aged 6–16 ( | Prospective observational study | Morphine | PTSD symptoms as per Child PTSD Reaction Index | Significant correlation between morphine dose received and 6-month decrease in PTSD symptoms |
|
| (5) Bryant et al., 2009 [28] | Hospitalized patients with traumatic injuries (; 17 with PTSD, 138 without) | Chart review | Morphine | Amount of morphine used in patients with and without PTSD | Patients diagnosed with PTSD at 3 months received significantly less morphine |
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| (6) Stoddard et al., 2009 [29] | Hospitalized children with burns, aged 1–4 (; complete data available only for 11 children) | Prospective observational study | Morphine | PTSD symptoms as per CDSC-B Child Stress Disorders Checklist-Burns Version | Significant correlation between morphine dose received and 6-month decrease in PTSD symptoms |
|
| (7) Holbrook et al., 2010 [30] | Military personnel with combat trauma (; 243 with PTSD, 453 without) | Chart review | Morphine | Rates of morphine use in patients with and without PTSD | Lower morphine use in those with PTSD (61%) than those without (76%; ) |
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