Lower Plasma Creatinine and Urine Albumin in Individuals at Increased Risk of Type 2 Diabetes with Factor V Leiden Mutation
Table 1
Participant characteristics of the total cohort and those subjects with available urine samples are displayed.
Characteristic
All subjects
Subjects with urine samples
Wildtype
FVL mutation
Wildtype
FVL mutation
1780
125
—
744
56
—
Gender (females/males)
0.75*
0.19*
Age (years)
0.26
0.72
Diabetes
99 (5.6%)
6 (4.8%)
0.71*
57 (7.7%)
3 (5.4%)
0.53*
Body weight (kg)
0.41
0.38
BMI (kg·m−2)
0.61
0.50
Lean body mass (kg)
0.29
0.32
HbA1c (%)
0.88
0.26
Blood pressure syst. (mmHg)
0.19
0.94
Blood pressure diast. (mmHg)
0.55
0.96
Insulin sensitivityOGTT (AU)
0.76
0.77
Fasting glucose (mmol/L)
0.34
0.19
Plasma creatinine (mg/dL)
0.07
0.24
Urine albumin (mg/L)
—
—
—
0.03
Plasma creatinine (mg/dL)**
—
—
—
Values represent means ± SE (standard error). For statistical analyses, nonnormally distributed parameters were log transformed. ISI: insulin sensitivity index. Significant differences are marked by bold font. Chi-square test; adjusted for age, gender, and lean body mass.