Research Article
Stochastic Model for Langerhans Cells and HIV Dynamics In Vivo
Table 4
Parameters for the stochastic model.
| | Parameter | Parameter description | Estimate |
| | The reverse transcriptase inhibitor
drug effect | 0.5 | | The protease inhibitor drug effect | 0.5 | | Rate of production of healthy cells
per unit time | 1.5 day−1mm−3 | | Rate of production of LCs
per unit time | 5 day−1mm−3 | | Death rate of healthy cells | 0.001 day−1 | | Death rate of healthy LCs | 0.005 day−1 | | Infection between uninfected cells
and free virus particles | 0.00024 day−1mm−3 | | Infection between uninfected cells
and HIV infected LCs | 0.00004 day−1mm−3 | | Infection between uninfected LCs
and free virus particles | 0.00045 day−1mm−3 | | Infection between uninfected LCs
and HIV infected LCs | 0.000015 day−1mm−3 | | Death rate of infected cells | 0.24 day−1 | | Viral induced death of infected cells | 0.239 day−1 | | Death rate of infected but not yet
virus producing cell | 0.24 day−1 | | Intracellular delay time | 0.5 | | Death rate of infected LCs | 0.03 day−1 | | Viral induced death rate of infected LCs | 0.025 day−1 | | Death rate of infective virus particles | 2.4 day−1 | | Viral production rate by infected cells | 90 day−1 | | Viral production rate by infected LCs | 62.5 day−1 |
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Where and + , values adapted from [13, 14].
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