Research Article

Mapping and Identification of the Urine Proteome of Prostate Cancer Patients by 2D PAGE/MS

Table 3

Functional characterization of the 11 identified proteins found only in PCa.

SwissProt accession numberProtein nameGene nameSubcellular locationType of proteinBiological function

ANT3_HUMANAntithrombin-III OS = Homo sapiens GN = SERPINC1 PE = 1 SV = 1SERPINC1Extracellular spaceEnzymeSerine protease inhibitor in plasma that regulates the blood coagulation cascade

AMY1_HUMANAlpha-amylase 1 OS = Homo sapiens GN = AMY1A PE = 1 SV = 2AMY1 Extracellular spaceEnzymeCarbohydrate metabolic process

UTP18_HUMANU3 small nucleolar RNA-associated protein 18 homolog OS = Homo sapiens GN = UTP18 PE = 1 SV = 3UTP18NucleusOtherIt is involved in nucleolar processing of pre-18S ribosomal RNA

TYPH_HUMANThymidine phosphorylase OS = Homo sapiens GN = TYMP PE = 1 SV = 2TYMPExtracellular spaceGrowth factorIt has a role in maintaining the integrity of the blood vessels, growth promoting activity on endothelial cells, angiogenic activity in vivo, and chemotactic activity on endothelial cells in vitro and catalyzes the reversible phosphorolysis of thymidine

ENDD1_HUMANEndonuclease domain-containing 1 protein OS = Homo sapiens GN = ENDOD1 PE = 1 SV = 2ENDOD1Extracellular spaceEnzymeIt may act as a DNase and a Rnase

RFFL_HUMANE3 ubiquitin-protein ligase rififylin OS = Homo sapiens GN = RFFL PE = 1 SV = 1RFFLCytoplasmEnzymeIt regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins and negatively regulates the tumor necrosis factor-mediated signaling pathway and p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation

QORL1_HUMANQuinone oxidoreductase-like protein 1 OS = Homo sapiens GN = CRYZL1 PE = 1 SV = 2CRYZL1CytoplasmEnzymeQuinone metabolic process

ILF2_HUMANInterleukin enhancer-binding factor 2 OS = Homo sapiens GN = ILF2 PE = 1 SV = 2ILF2NucleusTranscription regulatorIt functions predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation

TMIG1_HUMANTransmembrane and immunoglobulin domain-containing protein 1 OS = Homo sapiens GN = TMIGD1 PE = 2 SV = 1TMIGD1OtherOtherIntegral component of membrane

RAB36_HUMANRas-related protein Rab-36 OS = Homo sapiens GN = RAB36 PE = 2 SV = 2RAB36CytoplasmEnzymeProtein transport. It is probably involved in vesicular traffic

TPD52_HUMANTumor protein D52 OS = Homo sapiens GN = TPD52 PE = 1 SV = 2TPD52CytoplasmOtherB cell differentiation and anatomical structure morphogenesis and secretion