| Subset of macrophages | Factors driving macrophages polarization | Molecules expressed by polarized macrophages | Functional properties of polarized macrophages |
| M1 | IFN- + LPS, TNF | TLR2, TLR4, CD16, CD32, CD64, CD80, CD86, IL-12, IL-23, TNF-, IL-1, IL-6, Type I IFN, IL-1RI, IL-15Ra, IL-7R, CXCL9, CXCL10, CXCL11, CCL2, CCL3, CCL4, CCL5, CXCL8, CXCL16, CCR7, COX2, iNOS, and miR-26-2 | Proinflammatory properties, phagocytosis, and cytotoxic and antitumoral properties |
| M2a | IL-4, IL-13 | CD163, CD23, CD302, CD209, IL-10 Decoy IL-1RII, CCL17, CCL22, CCL24, CXCR1, CXCR2, miR-193b, and miR-222 | Anti-inflammatory properties and immunoregulatory functions drive type II responses |
| M2b | IC + TLR | CD163, IL-10, CCL1, miR-27a, miR-222, miR29b-1, and miR-132 | Anti-inflammatory properties and immunoregulatory functions drive type II responses |
| M2c | IL-10 | CD163, scavenger receptor A and B, CD14, CCR2, CCL16, CCL18, CXCL13, CD204, and CD206 | Suppression of immune responses and tissue remodeling |
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