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Chromatography Research International
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Chromatography Research International
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2014
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Article
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Tab 7
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Research Article
A Validated Stability Indicating RP-HPLC Method Development and Validation for Simultaneous Estimation of Aliskiren Hemifumarate and Amlodipine Besylate in Pharmaceutical Dosage Form
Table 7
Forced degradation studies of aliskiren and amlodipine.
Stress condition
Aliskiren
Amlodipine
% degradation
Purity of angle
Purity of threshold
% degradation
Purity of angle
Purity of threshold
Acid degradation
9.7%
0.436
0.628
9.1%
0.568
1.168
Alkali degradation
9.12%
0.513
0.714
6.15%
4.056
6.792
Oxidative degradation
8.22%
0.429
0.618
7.28
3.096
4.610
Photolytic degradation
1.31%
0.305
0.513
2.03%
1.051
1.307
Thermal degradation
8.05%
0.420
0.816
4.68%
1.099
1.936