Review Article

The Membrane Associated RING-CH Proteins: A Family of E3 Ligases with Diverse Roles through the Cell

Figure 2

Schematic indicating the role of MARCH1 and CD83 in the development of T regs. The short dashed line indicates that IL-10 induces MARCH1 expression. The long dashed line indicates that MARCH1 targets MHC II. The solid line indicates the final outcome of MARCH1 targeting MHC II.