Research Article
Modelling Hepatotoxicity of Antiretroviral Therapy in the Liver during HIV Monoinfection
Table 1
Medication and corresponding parameter values.
and IC
50 are from Supplementary Table
of [
30].
| | Medication | [μM] | | IC50 [μM] | TD50 [μM] | Reference |
| | Zidovudine (AZT) | 37.4195 | 0.85 | 0.1823 | 127.7868 | [32] | | Didanosine (DDI) | 28.2229 | 1.07 | 0.1794 | 275.3284 | [32] | | Lamivudine (3TC) | 21.8103 | 1.15 | 0.0298 | 170.5277 | [33] | | Stavudine (d4T) | 4.4603 | 1.13 | 0.552 | 431.6235 | [32] | | Efavirenz (EFV) | 31.6776 | 1.67 | 0.0054 | 53.8520 | [34] | | Atazanavir (ATV) | 7.0932 | 2.69 | 0.0136 | 85.1185 | [32] | | Nelfinavir (NFV) | 62.81 | 1.81 | 0.1668 | 72.8875 | [35] |
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