International Journal of Computational Mathematics

Research Article

Modelling Hepatotoxicity of Antiretroviral Therapy in the Liver during HIV Monoinfection

Table 2

Parameters used in simulations.
Par. Description ValueSource
Rate of creation of CD4+ cells from within the body 10
(mL)āˆ’1		[36]
Natural death rate of uninfected CD4+ cells0.01 [37]
Probability that HIV infects hepatocytes 0.2Estimate
Probability that hepatocyte becomes productively infected 0.3Estimate
Rate at which latently infected hepatocytes become productive 0.006Estimate
Rate of transmission of HIV in CD4+ cells0.00015 (mL)āˆ’1 [36]
Antigen-independent CTLs proliferation rate 20[23]
Rate at which CTLs kill infectious CD4+ cells50[38]
Rate at which CTLs kill infectious hepatocytes 1[21]
Antigen-dependent proliferation rate of CTLs0.2[39]
Death rate of infected CD4+ due to infection 0.5[40]
Rate of creation of hepatocytes from within the body 27200[41]
Natural death rate of hepatocytes 0.002[42]
Rate of transmission of HIV in hepatocytes0.000015Estimate
Death rate of latently infected hepatocytes 0.01Estimate
Death rate of infectious hepatocytes 0.5Estimate
Rate of clearance of CTLS by all means 0.15[21]
Average rate of production of virions by an infected CD4+ cells50,000[43]
Average rate of production of virions by an infected hepatocyte 1000Estimate
Death rate of HIV 2[40]
Rate of production of virions from macrophages 5[23]
Virions produced due to drug metabolism 100Estimate
Natural enzyme elevation14[44]
Rate of clearance of ALT from blood system 0.25[42]
Rate of generation of liver enzyme in the blood 2000[42]