Journal of Amino Acids

Research Article

Lauryl-poly-L-lysine: A New Antimicrobial Agent?

Table 1

Comparison of MIC between lauryl-PLL and conventional antibiotics.
Bacterial strainsLauryl-PLL
( M of linked lauric acid)		Sensitivity and name of conventional antibiotics
( M)
Staphylococcus aureus 250 Oxacillin: 1.25 (R)
Benzylpenicillin: 0.75 (R)
Vancomycin: ≤0.699 (S)
Teicoplanin: ≤0.32 (S)
Escherichia coli 1000 Ampicillin: ≥91.6 (R)
Amikacin: 13.66 (S)
Amoxicillin: 10.95 (S)
Clavulanic acid: 20.08 (S)
Pseudomonas aeruginosa 125 Ticarcillin: ≥333 (R)
Ceftazidime: ≥117 (R)
Amikacin: 27 (I)
Colistin: 1.7 (S)
A letter following the name of the antibiotics refers to the sensitivity to antibiotics: R: resistant; I: intermediate; S: sensitive. Based on the antibiograms of the bacterial strains tested, we selected some known and widely used conventional antibiotics, as well as polypeptide and glycopeptide antibiotics with activity similar to that with lauryl-PLL. Their sensitivity and their MICs were tested in nonresistant strains: S. aureus (Gram-positive) and P. aeruginosa, and E. coli (Gram-negative).