Development and Validation of a Novel RP-HPLC Method for Estimation of Losartan Potassium in Dissolution Samples of Immediate and Sustained Release Tablets

<table class="table-group" id="tab3"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td align="left">Parameters</td><td align="center">Specifications</td><td align="center">Day 1</td><td align="center">Day 2</td><td align="center">Day 3</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td align="left">Retention time (% RSD)</td><td align="center">≤2.0</td><td align="center">0.23</td><td align="center">0.32</td><td align="center">0.29</td></tr><tr><td align="left">Symmetry</td><td align="center">≤2.0</td><td align="center">0.92</td><td align="center">0.97</td><td align="center">0.94</td></tr><tr><td align="left">Area (% RSD)</td><td align="center">≤2.0</td><td align="center">0.97</td><td align="center">0.87</td><td align="center">0.89</td></tr><tr><td align="left">Theoretical plates (column)</td><td align="center">&gt;2000</td><td align="center">7878</td><td align="center">7804</td><td align="center">7858</td></tr><tr><td align="left">USP tailing</td><td align="center">&lt;2.0</td><td align="center">1.049</td><td align="center">1.043</td><td align="center">1.039</td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Chromatography Research International

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Table 3

Table 3: Development and Validation of a Novel RP-HPLC Method for Estimation of Losartan Potassium in Dissolution Samples of Immediate and Sustained Release Tablets 

Table 3 | Development and Validation of a Novel RP-HPLC Method for Estimation of Losartan Potassium in Dissolution Samples of Immediate and Sustained Release Tablets 