Development and Validation of a Novel RP-HPLC Method for Estimation of Losartan Potassium in Dissolution Samples of Immediate and Sustained Release Tablets

<table class="table-group" id="tab4"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td align="left">Concentration (mcg/mL)</td><td align="center">Area<sup>a</sup> (mAU)</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td align="left">5.5</td><td align="center">323.88911</td></tr><tr><td align="left">16.5</td><td align="center">990.68721</td></tr><tr><td align="left">33</td><td align="center">2205.75408</td></tr><tr><td align="left">44</td><td align="center">2952.47113</td></tr><tr><td align="left">55</td><td align="center">3842.69317</td></tr><tr><td align="left">66</td><td align="center">4544.43515</td></tr><tr><td align="left">82.5</td><td align="center">5726.98713</td></tr><tr><td align="left">104.5</td><td align="center">7260.89909</td></tr><tr><td align="left" colspan="2"><hr/></td></tr><tr><td align="left">Slope</td><td align="center">70.72</td></tr><tr><td align="left">Intercept </td><td align="center">−116.9</td></tr><tr><td align="left">Correlation coefficient (<svg height="15.975" id="M22" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 17.4 15.975" width="17.4" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,15.775)"><path d="M627 18l-10 -26q-79 6 -116 27t-69 76q-41 71 -71 138q-13 29 -27.5 39t-42.5 10h-46l-27 -145q-13 -74 -2.5 -88.5t78.5 -20.5l-6 -28h-271l5 28q66 6 82.5 21.5t30.5 87.5l71 387q12 66 2 78.5t-77 19.5l8 28h233q102 0 147 -29q65 -43 65 -129q0 -69 -45.5 -117
t-115.5 -72q40 -86 66 -133q39 -68 65 -101q28 -37 73 -51zM491 483q0 67 -33.5 101t-91.5 34q-35 0 -51 -10q-13 -8 -20 -48l-45 -245h49q71 0 113 28q79 52 79 140z" id="x1D445"></path></g>
<g transform="matrix(.012,-0,0,-.012,11.013,7.613)"><path d="M412 140l28 -9q0 -2 -35 -131h-373v23q112 112 161 170q59 70 92 127t33 115q0 63 -31 98t-86 35q-75 0 -137 -93l-22 20l57 81q55 59 135 59q69 0 118.5 -46.5t49.5 -122.5q0 -62 -29.5 -114t-102.5 -130l-141 -149h186q42 0 58.5 10.5t38.5 56.5z" id="x32"></path></g>
</svg>)</td><td align="center">0.999</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><svg height="13.625" id="M23" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 5.9749999 13.625" width="5.9749999" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.012,-0,0,-.012,.062,5.4)"><path d="M433 39l-85 -51q-27 0 -47 20q-16 16 -24 44q-5 -3 -24 -16.5t-27 -18.5t-23 -13.5t-25 -12t-19 -3.5q-52 0 -86 36.5t-34 85.5q0 71 81 99q128 43 155 65v17q0 54 -23 83.5t-62 29.5q-28 0 -45 -19t-29 -66q-7 -23 -29 -23q-15 0 -29 13t-14 30t31 40q25 19 68.5 40.5
t81.5 29.5q49 0 82 -27q45 -39 45 -123v-185q0 -60 35 -60q18 0 36 11zM275 84v156q-12 -6 -49 -23t-41 -19q-31 -14 -46 -31t-15 -43q0 -35 22.5 -55.5t48.5 -20.5q19 0 42 10.5t38 25.5z" id="x61"></path></g>
</svg>Average of three determinations. <br/></td></tr></table>

Chromatography Research International

tab4

Table 4

Table 4: Development and Validation of a Novel RP-HPLC Method for Estimation of Losartan Potassium in Dissolution Samples of Immediate and Sustained Release Tablets 

Table 4 | Development and Validation of a Novel RP-HPLC Method for Estimation of Losartan Potassium in Dissolution Samples of Immediate and Sustained Release Tablets 