Advances in Hepatology

Review Article

NADPH Oxidases in Chronic Liver Diseases

Table 1

The major NOX homologues expressed in the liver and their function.
NOX homologueExpressing cells in the liverFunction
NOX1HSC, hepatocytes, sinusoidal endothelial cells (SECs), and macrophagesHSC: liver fibrogenesis [18, 19], proliferation [20], senescence [19]
Hepatocyte: HCV-mediated oxidative stress [21]
Macrophage: oxidative stress, liver fibrogenesis [18]
SECs: unknown
NOX2Macrophages, HSC, SECs, and hepatocytesMacrophage: oxidative burst [10], liver fibrosis [22]
HSC: phagocytosis [18], liver fibrosis [18, 22–25]
Hepatocyte: unknown
SECs: unknown
NOX3HepG2
Unknown in primary liver cells		Unknown
NOX4Hepatocytes, HSC, and SECsHepatocyte: oxidative stress [21, 26], apoptosis [27–30]
HSC: liver fibrogenesis [28, 29]
SECs: unknown
NOX5Unknown 
Duox1Unknown 
Duox2Unknown