Research Article
Substrate Directed Regioselective Monobromination of Aralkyl Ketones Using N-Bromosuccinimide Catalysed by Active Aluminium Oxide: α-Bromination versus Ring Bromination
Table 7
Nuclear bromination of various aralkyl ketones containing high activating groupsa.
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Reaction conditions: aralkyl ketone(s) 1p–r (10 mmol), N-bromosuccinimide (12 mmol), and 10% (w/w) neutral Al2O3 in acetonitrile (20 mL) at reflux temperature. bIsolated yield. c22 mmol of NBS was utilized. |