Effects of 3-day treatment with M. macrophylla extracts combined or not with ICI 182,780 on the vaginal epithelial height (a) and microphotographs (b). animals treated with the vehicle (OVX); animals treated with estradiol benzoate at 0.75 μg/kg BW; animals treated with the dichloromethane extract of M. macrophylla; animals treated with the methanol extract of M. macrophylla. , , and compared with control; , , and compared with the same dose of each substance without ICI 182,780. Lu: lumen; Co: stratum corneum; Gr: stratum granulosum; Ge: stratum germinativum.