Development and Validation of a Rapid Chemometrics Assisted RP-HPLC with PDA Detection Method for the Simultaneous Estimation of Pyridoxine HCl and Doxylamine Succinate in Bulk and Pharmaceutical Dosage Form

<table class="table-group" id="tab3"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td align="left" rowspan="2">Responses</td><td align="center" rowspan="2">Lower limit</td><td align="center" rowspan="2">Upper limit</td><td align="center" colspan="2">Criteria I</td></tr><tr class="thead"><td align="center">Goal</td><td align="center">Importance </td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td align="left">tR<sub>2</sub></td><td align="center">3.108</td><td align="center">15.545</td><td align="center">Minimize</td><td align="center">3</td></tr><tr><td align="left">
                  Rs<sub>2</sub></td><td align="center">10.473 </td><td align="center">28.476</td><td align="center">Minimize</td><td align="center">3</td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Criteria for optimization of individual responses.

Chromatography Research International

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Table 3

Table 3: Development and Validation of a Rapid Chemometrics Assisted RP-HPLC with PDA Detection Method for the Simultaneous Estimation of Pyridoxine HCl and Doxylamine Succinate in Bulk and Pharmaceutical Dosage Form 

Table 3 | Development and Validation of a Rapid Chemometrics Assisted RP-HPLC with PDA Detection Method for the Simultaneous Estimation of Pyridoxine HCl and Doxylamine Succinate in Bulk and Pharmaceutical Dosage Form 