Factors Determining Survival and Retention among HIV-Infected Children and Adolescents in a Community Home-Based Care and a Facility-Based Family-Centred Approach in Kampala, Uganda: A Cohort Study
Table 3
Factors associated with attrition among HIV-infected children and adolescents in the CHBC model, Kampala, Uganda (2003–2010) using Cox regression.
Characteristics
Unadjusted (univariate analysis)
Adjusted* (multivariate analysis)
HR‡ (95% CI)
HR‡ (95% CI)
ART
No
1
<0.001
1
<0.001
Yes
0.06 (0.04–0.09)
0.04 (0.02–0.08)
Age (months)
<12
1
1
12–35
0.85 (0.65–1.10)
0.218
2.18 (0.97–4.92)
0.060
36–59
0.46 (0.33–0.64)
<0.001
1.65 (0.74–3.69)
0.225
60+
0.44 (0.35–0.56)
<0.001
1.38 (0.63–3.01)
0.418
Gender
Female
1
0.243
Male
1.11 (0.93–1.33)
Cd4 count and percent
CD4†
0.85 (0.78–0.93)
<0.001
0.84 (0.74–0.95)
0.006
CD4%†
0.80 (0.66–0.96)
0.016
Level of immunosuppression by CD4
Not significant
1
Mild
0.99 (0.66–1.49)
0.968
Advanced
0.89 (0.59–1.34)
0.590
Severe
1.87 (1.44–2.43)
<0.001
Age at ART initiation
Months†
0.85 (0.66–1.10)
0.209
WHO clinical staging
I-II
1
<0.001
1.94 (1.34–2.80)
<0.001
III-IV
1.84 (1.47–2.29)
Growth response weight-for-age
≤−2SD
1
0.007
>−2SD
0.76 (0.62–0.93)
Height-for-age
≤−2SD
1
<0.001
0.81 (0.60–1.09)
0.162
>−2SD
0.69 (0.56–0.84)
Hazard of attrition; †Log transformed due to skewed data;
*only factors significant at univariate or borderline were considered into multivariate.
