Research Article
Polymorphisms in the Sortilin-Related Receptor 1 Gene Are Associated with Cognitive Impairment in Filipinos
Table 3
Association analysis of the SORL1 SNPs in Filipinos with CI, MCI, and AD.
| | SORL1 SNPs | CI | MCI | AD | | value | OR (95% CI) | value | OR (95% CI) | value | OR (95% CI) |
| | SNP 8 | 0.225 | | 0.076 | | 0.829 | | | TT | | | | | | | | TC | 0.091 | 1.389 (0.949–2.033) | 0.028 | 1.710 (1.060–2.760) | 0.586 | 1.146 (0.701–1.875) | | CC | 0.857 | 1.056 (0.586–1.904) | 0.858 | 1.073 (0.498–2.320) | 0.914 | 0.959 (0.446–2.060) | | SNP 9 | 0.256 | | 0.101 | | 0.829 | | | AA | | | | | | | | GA | 0.102 | 1.375 (0.939–2.014) | 0.034 | 1.680 (1.040–2.715) | 0.586 | 1.146 (0.701–1.875) | | GG | 0.754 | 1.098 (0.612–1.970) | 0.682 | 1.171 (0.552–2.483) | 0.914 | 0.959 (0.446–2.060) | | SNP 10 | 0.256 | | 0.101 | | 0.829 | | | AA | | | | | | | | GA | 0.102 | 1.375 (0.939–2.014) | 0.034 | 1.680 (1.040–2.715) | 0.586 | 1.146 (0.701–1.875) | | GG | 0.754 | 1.098 (0.612–1.970) | 0.682 | 1.171 (0.552–2.483) | 0.914 | 0.959 (0.446–2.060) | | SNP 13 | 0.041 | | 0.316 | | 0.085 | | | AA | | | | | | | | GA | 0.667 | 0.348 (0.071–1.709) | 0.350 | 0.402 (0.060–2.795) | 0.173 | 0.256 (0.036–1.819) | | GG | 0.193 | 0.718 (0.159–3.249) | 0.671 | 0.676 (0.111–0.4112) | 0.629 | 0.641 (0.446–3.900) | | SNP 19 | 0.289 | | 0.177 | | 0.596 | | | TT | | | | | | | | TG | 0.120 | 1.529 (0.895–2.611) | 0.075 | 1.921 (0.920–4.014) | 0.317 | 1.421 (0.715–2.825) | | GG | 0.187 | 1.443 (0.837–2.488) | 0.082 | 1.965 (0.934–4.134) | 0.537 | 1.249 (0.617–2.528) | | SNP 23 | 0.055 | | 0.025 | | 0.309 | | | TT | | | | | | | | TA | 0.089 | 1.861 (1.123–3.085) | 0.007 | 2.708 (1.319–5.559) | 0.135 | 1.637 (0.858–3.123) | | AA | 0.016 | 1.581 (0.931–2.682) | 0.026 | 2.329 (1.105–4.908) | 0.425 | 1.321 (0.667–2.616) |
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