Research Article
Polymorphisms in the Sortilin-Related Receptor 1 Gene Are Associated with Cognitive Impairment in Filipinos
Table 4
SORL1 SNPs analyses that showed significant association in Filipinos with CI and MCI according to sex and age groups and APOE-ε4 carriage.
| | SORL1 SNPs | CI | MCI | AD | | value | OR (95% CI) | value | OR (95% CI) | value | OR (95% CI) |
| | Females | | | | | | | | SNP 13 | 0.045 | | 0.147 | | 0.169 | | | AA | | | | | | | | GA | 0.464 | 0.344 (0.020–5.974) | 0.214 | 0.156 (0.008–2.919) | | | | GG | 0.915 | 0.859 (0.530–13.865) | 0.509 | 0.391 (0.024–6.351) | | | | SNP 23 | 0.052 | | 0.033 | | 0.359 | | | TT | | | | | | | | TA | 0.017 | 2.156 (1.144–4.063) | 0.013 | 3.566 (1.300–9.778) | 0.154 | 1.783 (0.804–3.951) | | AA | 0.037 | 2.016 (1.043–3.895) | 0.011 | 3.762 (1.347–10.508) | 0.261 | 1.612 (0.701–3.708) | | ≤70 years old | | | | | | | | SNP 19 | 0.062 | | 0.113 | | 0.288 | | | TT | | | | | | | | TG | 0.029 | 2.742 (1.107–6.792) | 0.059 | 2.985 (0.960–9.281) | 0.125 | 5.118 (0.636–41.202) | | GG | 0.021 | 2.920 (1.172–7.277) | 0.038 | 3.328 (1.067–10.375) | 0.122 | 5.230 (0.644–42.463) | | SNP 23 | 0.555 | | 0.052 | | 0.534 | | | TT | | | | | | | | TA | 0.021 | 2.576 (1.127–5.887) | 0.018 | 3.864 (1.258–11.869) | 0.434 | 1.717 (0.443–6.653) | | AA | 0.025 | 2.670 (1.157–6.164) | 0.021 | 3.810 (1.225–11.850) | 0.265 | 2.149 (0.560–8.250) | | APOE-ε4 noncarriers | | | | | | | | SNP 8 | 0.125 | | 0.030 | | 0.778 | | | TT | | | | | | | | TC | 0.088 | 1.446 (0.946–2.211) | 0.019 | 1.865 (1.106–3.146) | 0.789 | 1.081 (0.611–1.913) | | CC | 0.556 | 0.815 (0.412–1.612) | 0.617 | 0.792 (0.318–1.973) | 0.575 | 0.771 (0.310–1.917) | | SNP 9 | 0.167 | | 0.050 | | 0.778 | | | AA | | | | | | | | GA | 0.100 | 1.429 (0.934–2.186) | 0.025 | 1.825 (1.080–3.084) | 0.789 | 1.081 (0.611–1.913) | | GG | 0.674 | 0.866 (0.422–1.695) | 0.824 | 0.905 (0.378–2.170) | 0.575 | 0.771 (0.310–1.917) | | SNP 10 | 0.167 | | 0.050 | | 0.778 | | | AA | | | | | | | | GA | 0.100 | 1.429 (0.934–2.186) | 0.025 | 1.825 (1.080–3.084) | 0.789 | 1.081 (0.611–1.913) | | GG | 0.674 | 0.866 (0.422–1.695) | 0.824 | 0.905 (0.378–2.170) | 0.575 | 0.771 (0.310–1.917) | | SNP 19 | 0.151 | | 0.091 | | 0.554 | | | TT | | | | | | | | TG | 0.062 | 1.818 (0.970–3.409) | 0.031 | 2.653 (1.095–6.426) | 0.393 | 1.439 (0.624–3.322) | | GG | 0.075 | 1.773 (0.945–3.327) | 0.046 | 2.468 (1.015–6.000) | 0.278 | 1.583 (0.691–3.629) | | SNP 23 | 0.008 | | 0.007 | | 0.162 | | | TT | | | | | | | | TA | 0.002 | 2.563 (1.410–4.657) | 0.002 | 4.023 (1.694–9.554) | 0.058 | 2.190 (0.973–4.933) | | AA | 0.020 | 2.073 (1.121–3.834) | 0.017 | 2.962 (1.216–7.215) | 0.114 | 1.954 (0.851–4.490) |
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