Inflammatory Response in Patients under Coronary Artery Bypass Grafting Surgery and Clinical Implications: A Review of the Relevance of Dexmedetomidine Use
Figure 7
Putative intracellular mechanisms involved in the (α-)2-adrenoreceptors activation. The (α-)2-adrenoreceptor subtypes are transmembrane receptors that can be coupled to different classes of G-protein. The activation of (α-)2-adrenoreceptor (α2R) inhibits adenyl cyclase (Ac) via activation of receptor-coupled Gi protein. This causes outward opening of the K+ channel via Gi protein, which results in cell hyperpolarization. The coupling of adrenoreceptors to G0 can either inhibit Ca2+ translocation or modulate phospholipase C (Pc). The coupling with an undetermined class of G protein (G?) stimulates an exchange of H+ and Na+ (Modified from [106]).
