Antinociceptive Effects of the Serotonin and Noradrenaline Reuptake Inhibitors Milnacipran and Duloxetine on Vincristine-Induced Neuropathic Pain Model in Mice
Figure 4
(Top) Schedule of drug administration. (Bottom) Vincristine (VCR; 0.1 mg/kg, i.p.) and duloxetine (Dul; 2.5, 5, 10, or 20 mg/kg, i.p.) were coadministered once per day for 7 days (days 0–6) to mice (a). Duloxetine (Dul; 2.5, 5, 10, or 20 mg/kg, i.p.) was administered to mice once per day for 7 days (days 7–13) after cessation of VCR (0.1 mg/kg, i.p.) administered once per day for 7 days (days 0–6) to mice (b). On day 7 (a) and day 14 (b), withdrawal responses to mechanical stimulation using a von Frey filament (0.4 g) were measured. Data are presented as mean ± S.E.M. for 10 mice in each group. Significance differences between the groups were assessed with one-way ANOVA followed by Dunnett’s test. compared with the saline control group; compared with the VCR group.
