International Scholarly Research Notices

Clinical Study

Pharmacodynamics Must Inform Statistics: An Example from a Cocaine Dependence Pharmacotherapy Trial

Systolic and diastolic blood pressure results as a function of titration data inclusion in the statistical model.


Parameter	Analysis excluding the one week titration phase					Analysis including the one week titration phase
Parameter	Estimate	SE	95% confid. limits			Estimate	SE	95% confid. limits

Systolic blood pressure
Intercept	123.68	1.94	119.87–127.48	63.66	<0.0001	124.80	1.74	121.38–128.21	71.66	<0.0001
Medication	−2.22	2.39	−6.91–2.47	−0.93	0.35	−3.54	2.24	−7.94–0.86	−1.58	0.11
Week	0.17	0.14	−0.11–0.45	1.22	0.22	0.01	0.13	−0.26–0.27	0.01	0.99
Med. by Week	−0.14	0.21	−0.54–0.26	−0.69	0.49	0.02	0.19	−0.36–0.40	0.09	0.93

Diastolic blood pressure
Intercept	78.48	1.51	75.52–81.45	51.82	<0.0001	79.33	1.28	76.82–81.84	61.84	<0.0001
Medication	−2.38	1.99	−6.27–1.52	−1.20	0.23	−2.91	1.66	−6.16–0.34	−1.75	0.08
Week	0.09	0.13	−0.17–0.35	0.67	0.51	−0.04	0.11	−0.25–0.17	−0.38	0.70
Med. by Week	−0.11	0.20	−0.50–0.28	−0.54	0.59	−0.03	0.16	−0.35–0.28	−0.18	0.85