Review Article
Nanotechnology in Cancer Drug Delivery and Selective Targeting
Table 1
Some formulations of nanoparticles with positive results in the recent investigations.
| | Type of nanoparticle | Anticancer drug | Targeting agent | Name of the polymers used | Outcome | Reference |
| | Polymeric nanoparticle | Cystatin | Cytokeratin specific monoclonal antibody | Poly(D, L-lactidecoglycolide) and polyethylene glycol | Prevent metastasis | [94] | | Polymeric nanoparticle | Paclitaxel | Monoclonal antibodies (antiHER2) | Poly(D, L-lactic acid) | Selective targeting | [95] | | Polymeric nanoparticle | Paclitaxel | Folic acid | Polylactic acid and polyethylene glycol | Enhanced drug accumulation in tumor | [96] | | Dendrimer | — | Folic acid | Polyamidoamine | Increased cellular uptake | [97] | | Nanoshell | Docetaxel | Folic acid | Biodegradable polymer | Sustainable, controlled, and targeted delivery | [98] | | Dendrimer | Small interfering RNA (siRNA) | Luteinizing hormone-releasing hormone (LHRH) peptide | Poly(propyleneimine) and polyethylene glycol | High specificity | [99] | | Nanoparticle | Paclitaxel | Folic acid | Poly(D, L-lactidecoglycolide) | Inhibition of P-glycoprotein | [100] | | Polymer micelle | Doxorubicin | Folic acid | PEG-co-poly(lactic-co-glycolic acid) | increased cellular uptake and cytotoxicity | [101] | | Polymer micelle | Doxorubicin | Folic acid | PEG-poly(aspartate hydrazone doxorubicin) | Increased endocytotic cellular uptake | [101] |
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