Research Article
Fast Stability Indicating UPLC Method for Quantitative Analysis of Dronedarone in Pharmaceutical Dosage Form: Force Degradation Study
Table 2
Summery of mobile phase optimization.
| | Solvent A | Solvent B | Remarks |
| Water
| Acetonitrile | Very broad peak with peak splitting | | 5 mM ammonium acetate | Methanol | Broad peak with peak tailing | | 5 mM ammonium acetate | Acetonitrile | Broad peak with peak tailing | | 1% orthophosphotic acid (OPA) in water | Acetonitrile | Peak eluted early with peak tailing | | 5 mM potassium dihydrogen phosphate (pH = 2.5 by OPA) | Methanol | Broad peak with peak tailing | | 5 mM potassium dihydrogen phosphate (pH = 2.5 by OPA) | Acetonitrile | Broad peak with peak tailing | | 5 mM potassium dihydrogen phosphate + 1 mL triethylamine (TEA) (pH = 2.5 by OPA) | Methanol | Good peak shape but retention time precision fail | | 20 mM potassium dihydrogen phosphate + 1 mL triethylamine (TEA) (pH = 2.5 by OPA) | Methanol | Good peak shape with good precision |
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