Fast Stability Indicating UPLC Method for Quantitative Analysis of Dronedarone in Pharmaceutical Dosage Form: Force Degradation Study

<table class="table-group" id="tab9"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td align="left">Stress condition</td><td align="center">Time</td><td align="center">Purity angle</td><td align="center">Purity threshold</td><td align="center">% degradation</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td align="left">Acid hydrolysis</td><td align="center">5 hr</td><td align="center">0.404</td><td align="center">0.978</td><td align="center">3.24</td></tr><tr><td align="left">Base hydrolysis</td><td align="center">1 hr</td><td align="center">1.045</td><td align="center">12.715</td><td align="center">24.07</td></tr><tr><td align="left">Oxidation</td><td align="center">1 hr</td><td align="center">3.297</td><td align="center">11.91</td><td align="center">18.56</td></tr><tr><td align="left">Thermal</td><td align="center">5 days</td><td align="center">0.573</td><td align="center">0.944</td><td align="center">2.37</td></tr><tr><td align="left">Photo</td><td align="center">5 days</td><td align="center">0.764</td><td align="center">1.363</td><td align="center">0.48</td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

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Table 9

Table 9: Fast Stability Indicating UPLC Method for Quantitative Analysis of Dronedarone in Pharmaceutical Dosage Form: Force Degradation Study 