Research Article
Chemical Exposure Generates DNA Copy Number Variants and Impacts Gene Expression
Table 2
CNVs generated by EMS exposure.
| Experiment | Concentration (mM) | Chromosome | Start (bp) | End (bp) | Length (kb) | Segmentation mean | Overlap with CNVEsa |
| 1 | 0.5 | 4 | 34804051 | 35101102 | 297.1 | 0.092 | No | 1 | 0.5 | 8 | 12592572 | 13822847 | 1230.3 | −0.088 | Yes | 1 | 0.5 | 9 | 50187567 | 50303563 | 116.0 | 0.248 | No | 1 | 0.5 | 14 | 16605821 | 16732619 | 126.8 | 0.276 | Yes | 1 | 0.5 | 24 | 35425802 | 35674998 | 249.2 | −0.173 | No | 1 | 2 | 4 | 22583174 | 22620167 | 37.0 | −0.792 | No | 1 | 2 | 5 | 32488684 | 32820694 | 332.0 | −0.222 | No | 1 | 2 | 5 | 64239559 | 64293196 | 53.6 | −0.391 | Yes | 1 | 2 | 6 | 49556168 | 50808094 | 1251.9 | −0.199 | No | 1 | 2 | 7 | 48895436 | 48948526 | 53.1 | 0.583 | Yes | 1 | 2 | 8 | 32921651 | 33404812 | 483.2 | −0.321 | No | 1 | 2 | 9 | 50190782 | 50306820 | 116.0 | 0.445 | No | 1 | 2 | 13 | 14841216 | 14864686 | 23.5 | 0.705 | No | 1 | 2 | 13 | 40036069 | 40492860 | 456.8 | 0.151 | Yes | 1 | 2 | 14 | 16612394 | 16785422 | 173.0 | 0.361 | Yes | 1 | 2 | 16 | 17135247 | 18061907 | 926.7 | 0.157 | No | 1 | 2 | 18 | 31915173 | 33340460 | 1425.3 | −0.235 | Yes | 1 | 2 | 20 | 8220598 | 8240372 | 19.8 | 0.799 | No | 1 | 2 | 20 | 16618414 | 16980789 | 362.4 | 0.196 | No | 1 | 2 | 21 | 8967733 | 9185499 | 217.8 | 0.244 | Yes | 1 | 2 | 21 | 21053248 | 21398259 | 345.0 | −0.228 | No | 1 | 2 | 25 | 31027622 | 31064013 | 36.4 | −0.579 | No | 1 | 5 | 14 | 16609009 | 16769181 | 160.2 | 0.282 | Yes | 2 | 0.5 | 4 | 22586693 | 22620167 | 33.5 | −0.739 | No | 2 | 0.5 | 5 | 32662667 | 32817496 | 154.8 | −0.441 | No | 2 | 0.5 | 7 | 87 | 418056 | 418.0 | −0.182 | Yes | 2 | 0.5 | 8 | 12566432 | 13625424 | 1059.0 | −0.138 | No | 2 | 0.5 | 13 | 51315349 | 51444199 | 128.9 | 0.363 | No | 2 | 0.5 | 14 | 27806152 | 34875942 | 7069.8 | −0.079 | Yes | 2 | 0.5 | 18 | 31506143 | 31908755 | 402.6 | 0.117 | No | 2 | 0.5 | 18 | 43478909 | 43530599 | 51.7 | −0.521 | No | 2 | 0.5 | 19 | 8399336 | 10004277 | 1604.9 | −0.109 | No | 2 | 0.5 | 24 | 35472028 | 35709297 | 237.3 | −0.231 | No | 2 | 5 | 4 | 22586693 | 22624474 | 37.8 | −0.905 | No | 2 | 5 | 5 | 32481902 | 32817496 | 335.6 | −0.398 | No | 2 | 5 | 5 | 37581072 | 38022638 | 441.6 | −0.226 | No | 2 | 5 | 5 | 64165549 | 65694964 | 1529.4 | −0.139 | Yes | 2 | 5 | 6 | 49600941 | 50828098 | 1227.2 | −0.268 | No | 2 | 5 | 7 | 87 | 355049 | 355.0 | −0.285 | Yes | 2 | 5 | 8 | 22262700 | 23108696 | 846.0 | −0.227 | Yes | 2 | 5 | 13 | 51328104 | 51486986 | 158.9 | 0.482 | No | 2 | 5 | 14 | 31449275 | 33739196 | 2289.9 | −0.159 | Yes | 2 | 5 | 18 | 27977948 | 31396054 | 3418.1 | −0.161 | Yes | 2 | 5 | 18 | 31911993 | 33198929 | 1286.9 | −0.260 | Yes |
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CNVEs as called in AB strain zebrafish in [22].
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