Targets susceptible to modification or alteration in HDL. The heterogeneity in HDL components renders these molecules very susceptible to alteration in various aspects. (a) depicts the protein targets, whereas (b) summarizes the lipid targets. These are studied by proteomics and lipidomics, respectively. HDL: High-Density Lipoprotein; SAA: Serum Amyloid A; LCAT: Lecithin-Cholesterol Acyltransferase; PON-1: Paraoxonase; ABCA-1: ATP-binding cassette transporter A-1; SR-B1: Scavenger Receptor B1; CETP: cholesteryl ester Transfer Protein.