International Scholarly Research Notices

Research Article

Development of Simultaneous Derivative Spectrophotometric and HPLC Methods for Determination of 17-Beta-Estradiol and Drospirenone in Combined Dosage Form

Table 2

The intraday and interday accuracy and precision analysis of ESR and DRS by derivative spectrophotometric and HPLC methods ().
MethodDrugConcentration
(µg mL−1) 		Intraday
Found ± RSD, % 		Interday
Found ± RSD, %
Derivative spectrophotometric methodESR 0.63 0.63 ± 0.32 0.56 ± 1.07
2.50 2.44 ± 0.01 2.38 ± 0.50
5.00 5.06 ± 0.01 4.94 ± 0.45
DRS 1.00 0.89 ± 1.35 0.88 ± 2.39
5.00 5.01 ± 1.94 4.93 ± 2.84
16.0016.31 ± 1.0416.28 ± 1.17
HPLC methodESR 0.63 0.62 ± 1.18 0.64 ± 1.03
1.25 1.26 ± 0.21 1.26 ± 0.79
5.00 5.00 ± 0.02 5.01 ± 0.08
DRS 0.16 0.16 ± 0.69 0.15 ± 2.67
0.63 0.63 ± 1.90 0.62 ± 2.58
1.25 1.26 ± 1.75 1.24 ± 0.15