Research Article

Development of Simultaneous Derivative Spectrophotometric and HPLC Methods for Determination of 17-Beta-Estradiol and Drospirenone in Combined Dosage Form

Table 4

Analysis of ESR and DRS in Angeliq tablets by developed methods (1 mg ESR and 2 mg DRS per tablet), .

Statistical valuesDerivative spectrophotometric methodHPLC methodDerivative spectrophotometric methodHPLC method
ESRDRS

Mean (mg) ± SD1.01 ± 0.0080.97 ± 0.0021.98 ± 0.0001.96 ± 0.007
Recovery (%)101979998
RSD (%)0.790.210.030.36