Clinical Study

Metastasectomy of Pulmonary Metastases from Osteosarcoma: Prognostic Factors and Indication for Repeat Metastasectomy

Table 2

Univariate analysis and multivariate analysis.

FactorUnivariateMultivariate
HR (95% CI)HR (95% CI)

Age (>15 vs. ≦15)0.38 (0.14–0.97)0.04*0.24 (0.08–0.68)0.01*
Sex (male vs. female)1.33 (0.54–3.30)0.53
Maximal diameter of the tumor at first metastasectomy1.55 (0.83–2.90)0.17
Total number of resected pulmonary metastases
at first metastasectomy (≦3 vs. >3)
0.28 (0.11–0.70)0.01*0.18 (0.06–0.51)<0.01*
Number of surgeries1.16 (0.77–1.75)0.47
Disease-free interval0.99 (0.96–1.02)0.53

HR: hazard ratio; CI: confidence interval.
* value less than 0.05.