HPB Surgery

Research Article

Hepatocellular Carcinoma in the Pediatric Population: A Population Based Clinical Outcomes Study Involving 257 Patients from the Surveillance, Epidemiology, and End Result (SEER) Database (1973–2011)

Table 5

Tumor characteristics of fibrolamellar and nonfibrolamellar hepatocellular carcinoma for 63,514 adults and 257 pediatric patients from the Surveillance, Epidemiology, and End Results (SEER) database, 1973–2011.


	Total		Pediatrics		Adults		value
	fHCC	Non-fHCC	fHCC	Non-fHCC	fHCC	Non-fHCC	value

(%)	274 (0.4%)	63,497 (99.6%)	62 (24.1%)	195 (75.9%)	212 (0.3%)	63,302 (99.7%)	—
Grade, (%)
Well differentiated	22 (26.8%)	7,791 (35.1%)	6 (37.5%)	28 (35.4%)	16 (24.2%)	7,763 (35.1%)	NS
Moderately diff.	41 (50.0%)	8,426 (38.0%)	8 (50.0%)	25 (31.6%)	33 (50.0%)	8,401 (38.0%)	NS
Poorly diff.	19 (23.2%)	5,298 (23.9%)	2 (12.5%)	20 (25.3%)	17 (25.8%)	5,278 (23.9%)	NS
Undifferentiated	0 (0.0%)	672 (3.0%)	0 (0.0%)	6 (7.6%)	0 (0.0%)	666 (3.0%)	NS
Stage, (%)
Localized	96 (37.2%)	25,659 (48.0%)	15 (25.0%)	53 (29.1%)	81 (40.9%)	25,606 (48.1%)	<0.001
Regional	86 (33.3%)	16,691 (31.2%)	24 (40.0%)	70 (38.5%)	62 (31.3%)	16,621 (31.2%)	<0.001
Distant	76 (29.5%)	11,117 (20.8%)	21 (35.0%)	59 (32.4%)	55 (27.8%)	11,058 (20.8%)	<0.001
Size, (%)
Microscopic	0 (0.0%)	45 (0.1%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	45 (0.1%)	NS
Under 2 cm	4 (2.0%)	3,067 (7.9%)	1 (1.8%)	15 (14.0%)	3 (2.0%)	3,052 (7.9%)	NS
2 to 4 cm	23 (11.2%)	11,697 (30.1%)	4 (7.3%)	13 (12.1%)	19 (12.7%)	11,684 (30.1%)	NS
Over 4 cm	178 (86.8%)	24,077 (61.9%)	50 (90.9%)	79 (73.8%)	128 (85.3%)	23,998 (61.9%)	NS

cm = centimeters; diff. = differentiated; fHCC = fibrolamellar hepatocellular carcinoma; = number; NS = not statistically significant with value > 0.05; NOS = not otherwise specified; SD = standard deviation; data presented for patients with available information only.