Advances in Pharmaceutics

Research Article

Formulation Development of Mouth Dissolving Film of Etoricoxib for Pain Management

Table 5

Evaluation of analgesic activity by tail flick test (reaction time).
TreatmentBasal reaction time (Sec)Reaction time (sec)
10 min20 min30 min40 min50 min
Control1.26 ± 0.061.27 ± 0.111.22 ± 0.051.25 ± 0.091.27 ± 0.081.19 ± 0.04
Marketed IR tablet1.44 ± 0.311.44 ± 0.25ns3.16 ± 0.36a (20%)8.83 ± 0.35b (86%)10.17 ± 0.04b (102%)>10 sec (>100%)
Etoricoxib MDF1.26 ± 0.141.58 ± 0.28ns3.53 ± 0.26a (26%)8.85 ± 0.50b (87%)10.18 ± 0.16b (102%)>10 sec (>100%)
Values are expressed as mean ± SD ( = 3); < 0.01; < 0.001; ns: not significant when compared to control; data were analyzed by using one-way ANOVA followed by Tukey-Kramer multiple comparison test.
The values in the parentheses indicate the percentage increase in reaction time.