Review Article
Human Urine Proteomics: Analytical Techniques and Clinical Applications in Renal Diseases
Table 2
Putative biomarkers for IgAN discovered by urine proteome analysis.
| | Protein biomarkers | Up/downregulation | Cohort | Technique | Type of biomarker | Reference |
| | GP2, vasorin, and EGF | ↓ | Healthy controls () and gAN patients () | Nano-LC-MS/MS | Diagnostic | [86] |
| | CLM9, protocadherin, uteroglobin, DDPIV, NHLC3, and SLAF5 | ↑ | Healthy controls () and IgAN patients () | Nano-LC-MS/MS | Diagnostic | [86] |
| | MBL | ↑ | IgAN patients () and control () | ELISA | Diagnostic | [87] |
| | sTfR | ↑ | IgAN patients () and control () | Latex-enhanced immunonephelometric assay | Diagnostic | [88] |
| | Albumin fragments, α-1-antitrypsin, and α-1-β- glycoprotein | ↑ | IgAN patients () and control () | 2DE-MALDI-TOF-TOF and ELISA | Prognostic | [123] |
| | LG3 | ↓ | IgAN patients () and control () | 2DE-MALDI-TOF-TOF and ELISA | Diagnostic | [123] |
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