International Scholarly Research Notices

Research Article

High Risk Stage 2 and Stage 3 Colon Cancer, Predictors of Recurrence and Effect of Adjuvant Therapy in a Nonselected Population

Table 1

Patient characteristics and univariate cox regression analysis of effect on recurrence-free survival.


	Stage 2	Cox HR for recurrence	95% CI	Stage 3	Cox HR for recurrence	95% CI	Total

Gender (%)
Male	78 (53)			46 (48)			124 (51)
Female	70 (47)			49 (52)			119 (49)
Age, median (iqr)	73,5 (63,7–80,0)			69,3 (62,9–76,7)			72,2 (63,2–79,5)
T-stage (%)
3	123 (83)	0,64	0,27–1,49	66 (69)	0,53	0,27–1,01	189 (78)
4	25 (17)			25 (26)			50 (21)
Tumor site (%)
Distal	62 (42)	1,1	0,52–2,33	48 (51)	0,47	0,24–0,91	110 (45)
Proximal	77 (52)			44 (46)			121 (50)
Poor differentiation (%)	13 (9)	na		25 (26)	1,89	0,98–3,70	38 (16)
LVI or PNI (%)	15 (10)	1,89	0,72–5,00	17 (18)	2,33	1,12–4,76	32 (13)
N-stage (%)
0	148 (100)			0			148 (61)
1	0			61 (64)	0,32	0,17–0,60	61 (25)
2	0			34 (36)			34 (14)
Median # LN examined (iqr)	13 (8–19)	0,92	0,87–0,98	13 (8–19)	0,97	0,93–1,01	13 (8–19)
Median # metastatic LN (iqr)	0			2 (1–6)	1,14	1,08–1,21	0 (0–2)
Median LNR (iqr)	0			0,29 (0,11–0,50)	11,64	4,10–32,99	0 (0–0,20)
Adjuvant therapy (%)	9 (6)	1,81	0,55–5,88	57 (60)	0,57	0,30–1,09	66 (27)
Recurrence (%)	29 (20)			39 (41)			68 (28)
Median OS (iqr)	6,38 (4,25–8,49)			5,00 (1,84–7,09)			5,84 (3,00–7,84)
Median RFS (iqr)	5,72 (2,38–7,97)			3,04 (1,01–7,04)			5,37 (1,65–7,58)
Total	148			95			243

HR = hazard ratio; CI = confidence interval; iqr = interquartile range; LVI = lymphovascular invasion; PNI = perineural invasion; LN = lymph node; LNR = lymph node ratio; OS = overall survival; RFS = recurrence-free survival.
For continuous variables, the hazard ratio is expressed per point increase.