Research Article

Effects of Swimming Exercise on Limbic and Motor Cortex Neurogenesis in the Kainate-Lesion Model of Temporal Lobe Epilepsy

Figure 5

Effects of 30 d swimming exercise on dendritic branch points and intersections in area CA3 of hippocampus. Photomicrographs and histogram bars showing the dendritic branch points and intersections of the surviving neurons in groups of 4-month-old male Wistar rats exposed to the following conditions: normal control (NC), normal control followed by swimming exercise (NC+EX), sham-operated control followed by swimming exercise (SC+EX), and kainic acid-induced lesioning and seizures (LO) followed by immediate, 1 d postlesion exposure to swimming exercise (L+EX) treatments. Magnification 40x. (A) Effects on dendritic branch point counts for immediate (1 d postgrouping for controls, 1 d postictal period for lesioned rats) exposure to the swimming exercise. (B) Effects on dendritic branch point counts for delayed (60 d postgrouping for controls, 60 d postictal period for lesioned rats) exposure to the swimming exercise. (C) Effects on dendritic intersection counts for immediate (1 d postgrouping for controls, 1 d postictal period for lesioned rats) exposure to the swimming exercise. (D) Effects on dendritic intersection counts for delayed (60 d postgrouping for controls, 60 d postictal period for lesioned rats) exposure to the swimming exercise. Bars represent dendritic branch points or intersections in means ± standard errors. Intergroup differences significant at and . -values for (A–D) 479.2, 526.9, 2610, and 1491, respectively.