Research Article
Alterations in Gene Expression of Components of the Renin-Angiotensin System and Its Related Enzymes in Lung Cancer
Table 1
Proteins of the classical renin-angiotensin system (RAS) and proteins with RAS-related functions.
| Name | Gene name | E.C. number | Function for RAS |
| Angiotensinogen | AGT | — | Precursor of Ang peptides | Renin | REN | 3.4.23.15 | Angiotensinogen to Ang I | Angiotensin-converting enzyme | ACE | 3.4.15.1 | Ang I to Ang II | Prorenin receptor | ATP6AP2 | — | Activates prorenin, receptor for renin and prorenin | Chymase | CMA1 | 3.4.21.29 | Ang I to Ang II | Neprilysin | MME | 3.4.24.11 | Ang I to Ang 1–7, Ang II to Ang 1–4 and 5–8 | Prolylendopeptidase | PREP | 3.4.21.26 | Ang I to Ang 1–7, Ang II to Ang 1–7 | Aminopeptidase A | ENPEP | 3.4.11.7 | Ang II to Ang III | Aminopeptidase N | ANPEP | 3.4.11.2 | Ang III to Ang IV | Angiotensin-converting enzyme 2 | ACE2 | | Ang 1 to Ang 1–9, Ang II to Ang 1–7 | Prolylcarboxypeptidase | PRCP | 3.4.16.2 | Ang II to Ang 1–7 | AT1 Ang II receptor subtype | AGTR1 | — | Ang II receptor subtype vasoconstriction, thirst | AT2 Ang II receptor subtype | AGTR2 | — | Ang II receptor subtype generally opposes AT1 effects | MAS | MAS1 | — | Ang 1–7 receptor | Insulin-regulated aminopeptidase | | 3.4.11.3 | Ang IV receptor (AT4) |
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