Peptide-Protein Interaction Studies of Antimicrobial Peptides Targeting Middle East Respiratory Syndrome Coronavirus Spike Protein: An In Silico Approach

Table 2

Piper ranking of docked complex based on cluster size, where peptides with () represent the experimentally validated against MERS-CoV and are considered as positive controls.

Rank	Peptide	Length	Definition	Species	Cluster
1	P9	30	Mouse Beta-defensin	Mouse	328
2	AP00225	31	RatNP-4 (rat defensin)	Rat	285
3	AP00180	32	Human defensin 5 (alpha defensin)	Human	277
4	AP00549	40	Plectasin (fungal defensin)	Fungus	270
5	AP00744	41	AvBD-5, chicken avian beta defensin)	Chicken	253
6	AP00729	29	Kalata B1 (cyclotides)	Plant	247
7	AP00764	24	Dermaseptin-S9	Frog	223
8	AP00223	32	RatNP-2 (rat alpha defensin)	Rat	219
9	HR2P	36	HR2 region of MERS-CoV	Synthetic	208
10	AP00160	28	Dermaseptin-S4	Frog	200
11	AP00174	31	Guinea pig neutrophil cationic peptide 1	Guinea pig	193
12	AP00730	31	Kalata B8 (cyclotides)	Plant	175
13	AP00222	32	RatNP-1 (rat alpha defensin,)	Rat	175
14	AP02663	23	Piscidins	Fish	171
15	AP01061	31	Circulin D (cyclotides)	Plant	163
16	AP01356	46	Cp-thionin II	Plant	160
17	AP00532	20	Lunatusin	Plant	157
18	AP02571	31	Cycloviolacin VY1 (cyclotides)	Plant	155
19	AP00692	30	HFIAP-3 (Hagfish cathelicidin)	Fish	148
20	AP00260	22	Maculatin 1.1	Frog	146
21	AP02733	55	Piscidin	Fish	144
22	AP00275	31	Circulin B (cyclotides)	Plant	143
23	AP01644	30	Brevinin-2-RN1	Frog	143
24	AP02148	50	Apl-AvBD16 (Beta def)	Bird	139
25	AP01065	31	Cycloviolacin 014 (cyclotides)	Plant	136
26	AP01022	31	Cycloviolin A (cyclotides)	Plant	134
27	AP00036	38	Bovine Beta-defensin 1	Bovine	127
28	AP00074	24	Brevinin-1	Frog	120
29	AP00340	25	Chrysophsin-2	Fish	120
30	AP00166	25	Pleurocidin	Fish	118
31	AP02830	43	ccBD (Channel Catfish beta def)	Fish	115
32	AP00181	32	Human defensin 6	Human	115
33	AP01788	43	Myticin C	molluscs	111
34	AP00179	33	Human neutrophil peptide-4 (Alpha def)	Human	97
35	AP00641	33	Pardaxin 1	Fish	96
36	AP00771	23	Magainin 1	Frog	90
37	AP00742	42	Chicken AvBD6 (Beta def)	Chicken	88
38	AP00144	23	Magainin 2	Frog	85
39	AP00846	43	Mundticin KS (Bacteriocin)	Bacteria	66