Mode of Action of Lactoperoxidase as Related to Its Antimicrobial Activity: A Review
Figure 4
Illustration of the interaction between the biodisponibility of a peroxidase, the (pseudo)halogen concentration in plasma, in saliva, and in milk, and the production of oxidant molecules. MPO: myeloperoxidase; SPO: salivary peroxidase; LPO: bovine lactoperoxidase; OClā: hypochlorite; and OSCNā: hypothiocyanite. Although chloride is the most available substrate compared to thiocyanate, bromide, and iodide, thiocyanate is the most effective substrate for the Compound I and hypothiocyanite could be produced at equal or superior levels compared to hypohalides.
