Review Article
Modulation of Aromatase by Phytoestrogens
Table 1
Inhibition of aromatase by phytoestrogen classification.
| Aromatase enzyme activity | Gene expression | Phytoestrogen classification | Microsome, cell, cell line, or tissue | Degree of inhibition | Reference |
| X | | Lignans/isoflavonoids | Placental microsomes, JEG-3 | Moderate to weak | [5] |
| X | | Flavones | Placental microsomes | Moderate to weak | [60] |
| X | | Flavonoids | Placental microsomes | Moderate to weak | [61] |
| X | | Lignans/flavonoids | Human preadipocytes | Moderate to weak | [62] |
| X | | Flavonoids | Placental microsomes/ovary | Moderate to weak | [63] |
| X | | Flavonoids | Placental microsomes | Moderate to weak | [64] |
| X | | Flavonoids | Placental microsomes | Moderate to weak | [65] |
| X | | Flavonoids | Placental microsomes | Moderate to weak | [66] |
| X | | Lignans/flavonoids/isoflavonoids/stilbenes | Placental microsomes | Moderate to weak | [67] |
| X | | Lignans/flavonoids/isoflavonoids | Placental microsomes, MCF-7, MB 231 | Moderate to weak | [68] |
| X | | Lignans/isoflavonoids | MCF-7 | Moderate to weak | [69] |
| X | ▾ | Flavones/isoflavonoids | Granulosa-luteal | Weak | [70] |
| X | ▾ | Isoflavonoids | MCF-7, SK-BR-3 | Moderate to weak | [71] |
| X | ▾ | Flavonoids/isoflavonoids/stilbenes | Placental microsomes, JEG-3, MCF-7, SK-BR-3 | Strong to moderate to weak | [72] |
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