Modulation of Aromatase by Phytoestrogens

Table 1

Inhibition of aromatase by phytoestrogen classification.

Aromatase enzyme activity	Gene expression	Phytoestrogen classification	Microsome, cell, cell line, or tissue	Degree of inhibition	Reference
X		Lignans/isoflavonoids	Placental microsomes, JEG-3	Moderate to weak	[5]
X		Flavones	Placental microsomes	Moderate to weak	[60]
X		Flavonoids	Placental microsomes	Moderate to weak	[61]
X		Lignans/flavonoids	Human preadipocytes	Moderate to weak	[62]
X		Flavonoids	Placental microsomes/ovary	Moderate to weak	[63]
X		Flavonoids	Placental microsomes	Moderate to weak	[64]
X		Flavonoids	Placental microsomes	Moderate to weak	[65]
X		Flavonoids	Placental microsomes	Moderate to weak	[66]
X		Lignans/flavonoids/isoflavonoids/stilbenes	Placental microsomes	Moderate to weak	[67]
X		Lignans/flavonoids/isoflavonoids	Placental microsomes, MCF-7, MB 231	Moderate to weak	[68]
X		Lignans/isoflavonoids	MCF-7	Moderate to weak	[69]
X	▾	Flavones/isoflavonoids	Granulosa-luteal	Weak	[70]
X	▾	Isoflavonoids	MCF-7, SK-BR-3	Moderate to weak	[71]
X	▾	Flavonoids/isoflavonoids/stilbenes	Placental microsomes, JEG-3, MCF-7, SK-BR-3	Strong to; moderate to weak	[72]