Genetic Markers Used for Risk Stratification in Multiple Myeloma

Table 1

Abnormalities associated with outcome in MM and techniques used for detection.

Abnormalities	Outcome	Test
t(4;14)(p16;q32)	Poor	FISH*
t(14;16)(q32;q23)	Poor	FISH
t(6;14)(p21;q32)	Good?	FISH
t(11;14)(q13;q32)	Good/neutral	FISH
Deletion 17p13	Poor	FISH
Deletion 13	Poor	Convenlional cytogenetics
Chromosome 1 abnormalities	Poor	FISH
Hyperdiploidy	Good	FISH or FCM**
(if not associated with deletion 17p13)

*Fluorescence in situ hybridization (FISH). **Flow cytometry.