Review Article
Synthesis and Structural Activity Relationship Study of Antitubercular Carboxamides
Table 3
SAR and MIC of pyrimidine carboxamides.
| Compd. number | R | R1 | R2 | R3 | R4 | % inhibition (µg/mL) |
| 31a | 4-OCH3 | CH3 | H | H | CH3 | 2 | 31b | 3-OPh | CH3 | H | H | CH3 | 27 | 31c | 3-OPh | CH3 | CH3 | H | H | 65 | 31d | 2-NO2 | Cl | H | H | H | 11 | 31e | 4-NO2 | CH3 | H | H | CH3 | 4 | 31f | 4-Cl | H | H | H | H | 6 | 31g | 4-OH | F | H | H | H | 18 | 31h | 4-NO2 | Cl | H | H | Cl | 18 | 31i | 4-OH | CH3 | H | CH3 | H | 12 | 31j | 4-OH | H | NO2 | H | H | 2 | 31k | 3-Cl | H | Cl | F | H | 48 | 31l | 4-NO2 | F | H | H | H | 4 | 31m | 4-NO2 | H | CH3 | CH3 | H | 13 | 31n | 4-NO2 | CH3 | H | CH3 | H | 12 | 31o | 3-NO2 | Cl | H | H | H | 26 | 31p | 3-NO2 | H | Cl | F | H | 29 | 31q | 3-NO2 | F | H | H | H | 24 | 31r | 3-Cl | H | H | F | H | 38 | 31s | 4-NO2 | H | H | OCH3 | H | 21 | 31t | 3-NO2 | H | H | Cl | H | 29 | 31u | 3-NO2 | H | H | CH3 | H | 28 | 31v | 3-NO2 | H | H | F | H | 30 |
| 32a | 3-NO2 | CH3 | H | H | H | 6 | 32b | 4-Cl | Cl | H | H | H | 26 | 32c | 4-NO2 | H | H | Cl | H | 9 | 32d | 3-OPh | H | CH3 | CH3 | H | 32 | 32e | 4-NO2 | H | H | H | H | 25 | 32f | 3-NO2 | H | CH3 | CH3 | H | 63 | 32g | 4-NO2 | H | Cl | F | H | 22 |
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