Synthesis and Structural Activity Relationship Study of Antitubercular Carboxamides

Table 3

SAR and MIC of pyrimidine carboxamides.

Compd. number	R	R^1	R^2	R^3	R^4	% inhibition (µg/mL)
31a	4-OCH3	CH3	H	H	CH3	2
31b	3-OPh	CH3	H	H	CH3	27
31c	3-OPh	CH3	CH3	H	H	65
31d	2-NO2	Cl	H	H	H	11
31e	4-NO2	CH3	H	H	CH3	4
31f	4-Cl	H	H	H	H	6
31g	4-OH	F	H	H	H	18
31h	4-NO2	Cl	H	H	Cl	18
31i	4-OH	CH3	H	CH3	H	12
31j	4-OH	H	NO2	H	H	2
31k	3-Cl	H	Cl	F	H	48
31l	4-NO2	F	H	H	H	4
31m	4-NO2	H	CH3	CH3	H	13
31n	4-NO2	CH3	H	CH3	H	12
31o	3-NO2	Cl	H	H	H	26
31p	3-NO2	H	Cl	F	H	29
31q	3-NO2	F	H	H	H	24
31r	3-Cl	H	H	F	H	38
31s	4-NO2	H	H	OCH3	H	21
31t	3-NO2	H	H	Cl	H	29
31u	3-NO2	H	H	CH3	H	28
31v	3-NO2	H	H	F	H	30
32a	3-NO2	CH3	H	H	H	6
32b	4-Cl	Cl	H	H	H	26
32c	4-NO2	H	H	Cl	H	9
32d	3-OPh	H	CH3	CH3	H	32
32e	4-NO2	H	H	H	H	25
32f	3-NO2	H	CH3	CH3	H	63
32g	4-NO2	H	Cl	F	H	22