Targeting Peroxisome Proliferator-Activated Receptors Using Thiazolidinediones: Strategy for Design of Novel Antidiabetic Drugs

Figure 2

Y-shaped binding cavity with the binding sites explored using the crystal structure of the heterodimer of the human RXRα and PPARγ ligand binding domains, respectively, bound with 9-cis retinoic acid and GI262570, a full agonist and coactivator peptides (PDB:1FM9).