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(I) Strong/full PPARγ agonists |
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(1) Endogenous ligands: | 9-HODE, 13-HODE, 15-deoxy-12,14-prostaglandin J2, Prostaglandin PGJ2 |
(2) Natural ligands of plant origin: |
(a) Unsaturated fatty acids and hydroxy unsaturated fatty acids | |
(b) Flavonoids: | Luteolin, Quercetin, Kaempferol, (-) Catechin 2-hydroxychalcone, Biochanin A, Genistein, 6-hydroxydaidzein |
(c) Stilbenes: | Resveratrol, Amorphastilbol |
(d) Amorfrutins: | Amorfrutin 1, Amorfrutin 2, Amorfrutin 3 |
(e) Polyacetylenes: | Falcarindiol |
(f) Sesquiterpene lactones: | Deoxyelephantopin |
(g) Diterpene quinone derivatives: | Sargaquinoic acid, Sargahydroquinoic acid |
(3) Synthetic strong PPARγ agonists: |
(a) Thiazolidinediones or Glitazones: | Rosiglitazone, Pioglitazone, Troglitazone, Ciglitazone Rivoglitazone, Englitazone |
(b) Non-thiazolidinediones: |
(i) L-tyrosine analogue: | Farglitazar |
(ii) Sulfonamide derivative: | INT 131 |
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(II) Selective/partial PPARγ agonists |
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(1) Thiazolidinediones: | Balaglitazone |
(2) Benzodiazole derivative: | Telmisartan |
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(III) DUAL PPARα/γ AGONISTS |
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(1) Thiazolidinediones: | Netoglitazone, experimental compounds KRP 297, MK 767, DRF 2189 |
(2) Glitazars or non-thiazolidinediones | Muraglitazar, Tesaglitazar, Navaglitazar, Ragaglitazar Aleglitazar |
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(IV) PPAR panagonists (agonists of PPARα/β/γ subtypes) |
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(1) Fibrate drug | Benzafibrate |
(2) Miscellaneous, non-thiazolidinedione derivative | Chiglitazar |
(3) Fibric acid derivative | Experimental compound ZBH201102 |
(4) Thiazole derivative | GW-677954 |
(5) Oxazole derivative | LY-465608 |
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(V) SPPARγM (selective PPARγ modulator) (Phenylacetic acid derivative) | Metaglidasen |
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(VI) NOVEL PPARγ/FFAR1 DUAL AGONISTS |
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(1) Thiazolidinediones | Experimental compounds KM-1, KM-2, KM-5 |
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