|
| Shell and Core | Cargo/label | NP preparation method | Conjugation technique | Average size (nm) | Zeta potential (mV) | Reference |
|
| Chitosan/PEG functionalized PLGA core | Fluoresceinamine (FA) | O/W emulsification solvent evaporation | Covalent conjugation | 329 (FA-chitosan-PLGA)
324 (FA-PEG-PLGA) | 19.7 (FA-chitosan-PLGA)
−38.1 (FA-PEG-PLGA) | [79] |
|
| Chitosan-PLGA engineered into mesenchymal stem cell | Paclitaxel, Curcumin | O/W emulsification solvent evaporation | Chemical conjugation | 142 | 9.22 | [80] |
|
| Heparin/chitosan-Pluronic on PEG-PLGA core | Tetramethyl
rhodamine isocyanate | Nanoprecipitation/solvent diffusion | Chemical conjugation | 144 (Hep-PLGA),
134 (Ch-PLGA) | −50 (Hep-PLGA), +38 (Ch-PLGA) | [81] |
|
| Chitosan coated on PLGA | siRNA | Double emulsification solvent evaporation | Surface adsorption | 263.73 | 33.76 | [82] |
|
| Lecithin/chitosan on PLGA core | Betamethasone-17-valerate (BSV) | Emulsion-diffusion evaporation | Ionic gelation | 280.9 (BSV-chitosan-PLGA)
274 (BSV-chitosan-lecithin) | −5.62 (BSV-chitosan-PLGA)
40.8 (BSV-chitosan-lecithin) | [83] |
|
| 6-Carboxyfluorescein-chitosan film on paclitaxel-PLGA core | siRNA | O/W emulsification solvent evaporation | Surface adsorption as film | 204–543 | +16.9–31.2 | [84] |
|
| Dextran-cholesterol on PLA core | 99mTc | Co-dialysis | Covalent attachment | 119–201 | — | [85] |
|
| Dextran-cholesterol on PLA core | Fluorescein isothiocyanate | O/W emulsification solvent evaporation | Covalent attachment | 105 | | [86] |
|
| Dextran-cholesterol-aldehyde on PLA core | Transferrin, fluorescein isothiocyanate | Co-dialysis method | Covalent attachment | 100–150 | | [87] |
|
| Alginate-chitosan on PLGA core | Folic acid or Folic acid-PEG | Emulsion solvent evaporation | Covalent attachment | — | — | [88] |
|
| Dextran-sulphate sodium and PLGA core | Vincristine sulphate | Nanoprecipitation | Self-assembly | 128.3–133.0 | (−10.6)–(−13.8) | [89] |
|
| Trimethylated chitosan- on PLGA core | Coenzyme and Coumarin-6 | Nanoprecipitation | Covalent attachment | 136.8–146.7 | 17.7–21 | [90] |
|
| Chitosan-4-thiobutylamidine on PLGA core | Curcumin | Emulsification solvent evaporation | Covalent attachment | 889.5 | 24.75 | [91] |
|
| Chitosan on PLGA core | Mitoxantrone | Emulsion solvent evaporation | Adsorption and covalent attachment | 291 (adsorption)
331 (covalent binding) | 25.13 (adsorption),
23.01 (covalent binding) | [92] |
|
